Product: Ultimate Antioxidant
Company: Natural Factors
Size: 60 Capsules
Ingredients: N-Acetyl Cysteine 100mg, Alpha-Lipoic Acid 50mg, Grape Seed Phytosome 25mg, Green Tea Phytosome 25mg, Curcumin 25mg, Rosemary Leaf Extract ( Rosmarinus officinalis ) ( Carnosic Acid 0.45mg ) 7.5mg, Lutein ( from Marigold extract ) 1.5mg, Lycopene ( from 25mg Lyc-O-Mato tomato extract ) 1.5mg, Sulforaphane ( from broccoli powder ) 100mg, Zeaxanthin 66mcg.
Dosage: One to two capsules, two times daily or as directed by a health practitioner. Keep out of reach of children.
Contains no artificial preservatives, colour or sweeteners; no dairy or yeast.
Description: The Ultimate Antioxidant Complex is a formulation of powerful protectors against the cellular damage that underlies the aging process as well as many disease processes including heart disease, diabetes, arthritis, and cancer. The complex is unique because it is effective in both water- and fat-soluble environments inside and outside of cells, having the ability to recharge other antioxidants within the body and energize antioxidant enzymes to protect us from free radicals.
Why needed? A primer on free radicals, pro-oxidants, and antioxidants.
Simply defined, a free radical is a highly reactive atom that can destroy body tissues. Normally, an atom's electrons come in pairs. If one of the electrons gets stripped away, the atom--now a free radical--becomes unstable. It sets off on a frantic search to find another electron to complete its set, grabbing onto any electron it can find. But by stealing electrons, free radicals destroy those other molecules. Because the oxygen atom is most often involved as the donor of the electron, this damaging process is known as oxidation, and is similar to the process that causes sliced apples to turn brown or cars to rust. Compounds that promote oxidative damage are referred to as pro-oxidants.
Free radicals come from our environment, in pollutants such as chemicals or cigarette smoke; in our diet in the form of fats damaged by frying or the presence of nitrates in smoked or cured meats. Even sunlight produces free radical damage. But free radicals also result from the cell's own metabolic activity.
Free radicals shoot through the cell's membranes, tearing gaping holes, damaging the cell's delicate structures, including DNA, ( the cumulative damage they cause leads to cellular aging ). This, in turn, contributes to heart disease and cancer. Carcinogens ( cancer-causing compounds ) cause severe free radical or oxidative damage to cell structures.
Antioxidants quench the unpaired electron by donating one of its own electrons, effectively "calming down" the free radical, resulting in help for aging, cancer and other degenerative diseases. Because they protect cell integrity, antioxidants slow down the aging process, enhance immune function, reduce inflammation, and fight allergies.
What makes the Ultimate Antioxidant Complex so ultimate?
Notice that the Ultimate Antioxidant Complex does not contain vitamin C, zinc, selenium, beta-carotene, and vitamin E. Why? The Ultimate Antioxidant Complex is designed to be used along with a high potency multiple vitamin and mineral supplement ( such as the MultiStart age and gender specific multiples from Natural Factors ), creating powerful full spectrum antioxidant effects.
The importance of full-spectrum protection
Researchers often mistakenly focus on the effects of just one nutrient, which is like judging an entire symphony by listening to a single trombone. Each may have a somewhat different ( and narrow ) range of activity. For example, beta-carotene is an effective quencher of a free radical known as singlet oxygen, but is virtually powerless against the dozens of other types of free radicals. As a result, it has a very narrow range of benefit and is susceptible to damage without additional support.
Most antioxidants require some sort of "partner" antioxidant that allows it to work more efficiently. And scientists have discovered that it is quite easy for one antioxidant nutrient like beta-carotene to become damaged if it's used alone ( that is, without its partner antioxidants vitamin C, vitamin E, and selenium ). Similarly, selenium functions primarily as a component of the antioxidant enzyme glutathione peroxidase. This enzyme works closely with vitamin E to prevent free radical damage to cell membranes. Studies looking only at vitamin E's ability to reduce cancer and heart disease are often faulty because they failed to factor in the critical partnership between selenium and vitamin E, not to mention the interrelationship between vitamin E and coenzyme Q10.
In addition to exerting benefit on their own, phytochemicals and plant-derived antioxidants are well known to potentiate the activities of vitamin and mineral antioxidants.
Complete antioxidant protection, how?
Why N-Acetyl-Cysteine ( NAC )?
NAC is a derivative of the naturally occurring amino acid, cysteine. It boosts tissue levels of glutathione--a small protein composed of three amino acids--cysteine, glutamic acid, and glycine. Glutathione is involved in detoxification mechanisms, binding to fat-soluble toxins like heavy metals, solvents, and pesticides to transform them into a water-soluble form allowing more efficient excretion via the kidneys.
Glutathione's combination of detoxification and free radical protection makes it one of the most important cancer and aging fighters in our cells. Without the protection of glutathione, your cells die at a faster rate, making you age more quickly and putting you at risk for toxin-induced diseases including cancer. People who smoke, who are chronically exposed to toxins, who suffer from inflammatory conditions such as rheumatoid arthritis or chronic conditions such as diabetes, AIDS, or cancer typically have lower levels of glutathione.
Why Alpha Lipoic Acid?
Alpha lipoic acid is regarded by many as the "perfect" antioxidant. Scientists have known about alpha lipoic acid, a vitamin-like substance, since the 1930's when it was isolated from potatoes. Alpha lipoic acid is a very small molecule that is efficiently absorbed and easily crosses cell membranes, quenching either water- or fat-soluble free radicals both inside the cell and outside in the intracellular spaces, extending the biochemical life of vitamin C and E as well as other antioxidants.
Alpha lipoic acid is an approved drug in Germany, used for the treatment of diabetic neuropathy ( nerve disease ) for over 30 years. The value in diabetic neuropathy has been confirmed in several double-blind studies. In studies alpha-lipoic acid:
Why Grape Seed Phytosome?
Grape seed extract contains proanthocyanidins ( also referred to as procyanidins, OPCs, and PCOs )--one of the most beneficial groups of plant flavonoids. Grape Seed Phytosome is made by taking these molecules and binding them to phosphatidylcholine ( from soy lecithin ) to create an entirely new molecule that is better absorbed and utilized by the body. It is estimated that 50mg of Grape Seed Phytosome is equivalent to roughly 150mg of unbound grape seed extract.
The antioxidant action of PCOs is approximately 50 times greater than that of vitamins C and E. This is one of the most advantageous features of PCOs, since PCOs protect against both water- and fat-soluble free radicals, providing incredible protection to the cells.
Why Green Tea Phytosome?
Green Tea Phytosome provides the beneficial compounds of green tea ( polyphenols ) in the Phytosome form for enhanced absorption. Green tea polyphenols are potent antioxidant compounds, and increases the activity of antioxidant enzymes in the small intestine, liver, and lungs. The ability of green tea extract to protect against oxidative damage to LDL-cholesterol indicates that it may protect against atherosclerosis and heart disease. Studies have demonstrated that green tea polypheols inhibit cancer.
The value of Curcumin
Curcumin is the yellow pigment of turmeric ( curcuma longa )--the chief ingredient in curry, with beneficial antioxidant and anti-inflammatory effects. One of the advantages of curcumin over vitamins C and E is that while these nutritional antioxidants are effective against only water- and fat-soluble pro-oxidants, respectively, curcumin is effective in protecting against both. Curcumin enhances the body's levels of antioxidant compounds such as glutathione and superoxide dismutase, promoting the proper detoxification of cancer-causing compounds by the liver. Cigarette smokers receiving curcumin demonstrate significant reduction in the level of urinary-excreted mutagens--an indication of the ability of the body to rid cancer-causing compounds via detoxification mechanisms.
Rosemary extract standardized for carnosic acid
Natural polyphenols such as carnosic acid found in rosemary have potent antioxidant activities. Unlike vitamin C or E, which have little impact on protecting against damage to DNA, rosemary extract and carnosic acid have been shown to offer significant protection against DNA damage. Rosemary extract also works synergistically with lycopene ( see below ) in protecting against free radical damage to LDL cholesterol. When lycopene is combined with rosemary extract there is significant protection against LDL damage.
The value of lycopene
The antioxidant lycopene is a red-coloured carotene found primarily in tomatoes. Harvard researchers found that of all of the carotenoids only lycopene was clearly linked to protection against prostate, breast, and colon cancer, and a statistically significant association between high dietary lycopene and a lower risk of heart disease.
The antioxidant lutein is a yellow-orange carotene that appears to offer significant protection against macular degeneration. The macula is the area of the retina where images are focused. The macula, especially the central portion of the macula ( the fovea ) owes its yellow colour to its high concentration of lutein. Lutein intake may protect against macular degeneration, cataract formation and coronary artery disease.
Broccoli extract and sulforaphane stimulate detoxification
Sulforaphane and similar compounds found in broccoli are antioxidants and potent stimulators of natural detoxifying enzymes in the body. These compounds are believed to be responsible for the lowered risk of cancer associated with the consumption of broccoli and other cruciferous vegetables.
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